CDOS

B-Cell Gene Rearrangements Profile, IGH and IGK

Test Code: 481222

Performing Lab: LabCorp

CPT Code: 81264 001 81261 001

Test Link (Copy)

Synonym

IGH Clonality Assay; IGH Gene rearrangement Assay; IGK Clonality Assay; IGK Gene Rearrangement Assay

Specimen Type

Whole blood, bone marrow, formalin-fixed, paraffin-embedded (FFPE) tissue block or slides, fresh or frozen tissue

Specimen Container

Lavender-top (EDTA) tube, yellow-top (ACD) tube, green-top (heparin) tube, Tan-top (K2-EDTA) tube, and Pink-top (K2-EDTA) tube, FFPE tissue block or slides, tissue in RPMI or frozen

Volume

3 to 5 mL whole blood, 1 mL bone marrow, five unstained slides at 10 uM or formalin-fixed, paraffin-embedded tissue block, tissue in RPMI or frozen.

Minimum Volume

0.5 mL whole blood, 0.5 mL bone marrow, two unstained slides at 10uM

Specimen Handling

Fresh tissue should be placed in RPMI medium or shipped frozen on dry ice. Small samples (eg, punch biopsies, fine- needle aspirates) will also be accepted. To avoid delays in turnaround time when requesting multiple tests on frozen samples, please submit separate frozen specimens for each test requested.

Unacceptable Conditions

Frozen whole blood/bone marrow; quantity not sufficient for analysis; tumor tissue; broken or stained slides.

Temperature

Maintain blood, bone marrow or tissue in RPMI at 2(degrees)C -8(degrees)C, FFPE specimens at room temperature, tissue at -80(degrees)C

Methodology

Polymerase chain reaction (PCR)

TAT

5 - 7 days

Result Code	Result Name	LOINC
480717	B-Cell PCR Interpretation	21747-1
480827	B Clonal Size	UNLOINC
480778	Block Number:	UNLOINC
489025	Director Review:	72486-4
480720	Methodology:	49549-9
481529	References:	UNLOINC
480813	IgK PCR Interpretation	21748-9
480828	K Clonal Size	UNLOINC
480777	Block Number:	UNLOINC
489028	Director Review	72486-4
480831	Methodology:	49549-9
480842	References:	UNLOINC

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