Immunofixation, Daratumumab-Specific, Serum
Test Code: 123218
Performing Lab: LabCorp
CPT Code: 82784 003 86334 001
Synonym
Daratumumab Immunofixation Reflex Assay (DIRA); Electrophoresis, Serum, IFE; HYDRASHIFT 2/4 daratumumab; IEP, Serum; IFE, Serum; Immunoelectrophoresis, Serum; Immunofixation; Serum IEP; Serum Immunoelectrophoresis; Serum Immunofixation
Specimen Type
Serum
Specimen Container
Red-top tube or gel-barrier tube
Volume
2 mL
Minimum Volume
1 mL
Specimen Handling
Separate serum from red cells.
Patient Prep
Overnight fasting is preferred, but not required.
Unacceptable Conditions
Plasma sample
Temperature
Room temperature
Methodology
Electrophoresis followed by immunodiffusion against mono- specific antisera to immunoglobulin and individual heavy and light chains (IFE); turbidimetric quantitation of IgA, IgG, IgM. The HYDRASHIFT 2/4 daratumumab gel shift assay uses an anti-daratumumab antibody to allow for the migration of Daratumumab/anti-daratumumab complexes away from the gamma globulin zone on IFE, toward the alpha-1-globulin fraction, thus removing IgG kappa interference in the gamma globulin zone caused by Daratumumab in the patient's serum.
Stability
Room Temperature: 14 days
Refrigerated: 14 days
Frozen: 14 days
Refrigerated: 14 days
Frozen: 14 days
| Result Code | Result Name | LOINC |
|---|---|---|
| 123219 | IFE, Serum | 14895-7 |
| 001776 | Immunoglobulin G, Qn, Serum | 2465-3 |
| 001784 | Immunoglobulin A, Qn, Serum | 2458-8 |
| 001792 | Immunoglobulin M, Qn, Serum | 2472-9 |
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