CDOS

IDH1/IDH2 Mutation Analysis

Test Code: 481484

Performing Lab: LabCorp

CPT Code: 88381 001 81120 001 81121 001

Test Link (Copy)

Synonym

IDH1; IDH2; Isocitrate dehydrogenase 1 and 2; NADP+

Specimen Type

Whole blood, bone marrow, formalin-fixed, paraffin-embedded (FFPE) tissue block OR slides

Specimen Container

Lavender-top (EDTA) tube, green-top (heparin) tube, yellow-top (ACD) tube, Tan-top (K2-EDTA) tube, OR Pink-top (K2-EDTA) tube FFPE tissue block and slide container

Volume

3 to 5 mL whole blood, 1 to 2 mL bone marrow, four pre-cut unstained slides at 5 micron with one matching H&E reference slide, OR formalin-fixed, paraffin-embedded tissue (FFPE) block

Minimum Volume

3 mL whole blood, 1 mL bone marrow, two unstained slides at 5um AND one matching H&E slide OR three unstained slides at 5um. Tumor surface area >=4mm2 tumor area and >/= 50% tumor content are preferred

Unacceptable Conditions

Specimen does not meet all of the above criteria for sample type, container, minimum volume, collection and storage; unsuitable specimens include but are not limited to: frozen whole blood or marrow; a leaking tube; clotted blood or marrow; a grossly hemolyzed specimen or otherwise visibly degraded; specimen suspected of being contaminated by another specimen; specimen contains suspicious foreign material; no tumor tissue in FFPE block or slides; broken or stained slides

Temperature

Refrigerate. Maintain FFPE blocks/slides at room temperature

Methodology

SNaPshot Multiplex PCR (primer extension-based method)

Result Code	Result Name	LOINC
481485	IDH1 Result	100022-3
481486	IDH1 Nuc Change	48004-6
481487	IDH1 Amino Acid Change	48005-3
481488	IDH2 Result	50397-9
481489	IDH2 Nuc Change	48004-6
481490	IDH2 Amino Acid Change	48005-3
481491	Indication	42349-1
481492	Location	UNLOINC
481493	Specimen Type	31208-2
481494	Block ID	57723-9
481495	Background	8251-1
481979	Method	49549-9
481497	References	75608-0
481498	Director Review	72486-4
480903	Microdissection Performed	8100-0

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