DNA Double Strand Antibody, IgG, Serum
Test Code: ADNA
CPT Code: 86225
Test Name
DNA Double Strand Antibody, IgG, Serum
Epic Test Code
LAB2105
Alias
ANTI-dsDNA; Double Stranded DNA Antibody
Specimen Type
One 1.0 mL (min: 0.5 mL) serum refrigerated
Specimen Container
One gold gel 5.0 mL (also acceptable: one plain red 6.0 mL)
Specimen Handling
Separate serum from cells within 2 hours of collection
Unacceptable Conditions
Hemolyzed specimens (dependent on the level of hemolysis); lipemic specimens
Methodology
Fluoroenzymeimmunoassay
Schedule
Weekdays
Reporting Time
Final: 5 days
Additional Information
Interpretive Information: The amount of antibody detected is measured by Fluoroenzymeimmunoassay (Phadia) does not directly correlate to a specific immunofluorescence titer. Results of 10 to 15 IU/mL are considered equivocal and will flag abnormal with recommendation to retest the patient after 8 to 12 weeks.
Clinical Significance: Double-stranded DNA (dsDNA) IgG antibodies are an accepted criterion (American College of Rheumatology) for the diagnosis of idiopathic Systemic Lupus Erythematosus (SLE), dsDNA antibodies are detectable in approximately 85% of patients with untreated SLE and are rarely detectable in other connective tissue diseases. Weakly-positive results caused by low-avidity antibodies to dsDNA are not specific for SLE and can occur in a variety of diseases.
Clinical Significance: Double-stranded DNA (dsDNA) IgG antibodies are an accepted criterion (American College of Rheumatology) for the diagnosis of idiopathic Systemic Lupus Erythematosus (SLE), dsDNA antibodies are detectable in approximately 85% of patients with untreated SLE and are rarely detectable in other connective tissue diseases. Weakly-positive results caused by low-avidity antibodies to dsDNA are not specific for SLE and can occur in a variety of diseases.
Stability
Ambient: Unacceptable / Refrigerated: 1 Week / Frozen: 2 Weeks
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