Treponema Pallidum IgG TPPA
Test Code: MHATP
CPT Code: 86780
Test Name
Treponema Pallidum IgG TPPA
Epic Test Code
LAB1308
Alias
Syphilis Confirmatory; T. pallidum IgG by TPPA
Specimen Type
One 1.0 mL (min: 1.0 mL) serum refrigerated
NOTE: Microtainer Minimum: 1.0 mL
NOTE: Microtainer Minimum: 1.0 mL
Specimen Container
One gold gel 5.0 mL (also acceptable: one plain red 6.0 mL or three gold gel microtainers (clear or amber) 600 mcL )
Specimen Handling
Separate serum from cells within 2 hours of collection
Unacceptable Conditions
Hemolyzed specimens (dependent on the level of hemolysis); lipemic specimens; other body fluids; plasma specimens
Methodology
Particle Agglutination
Schedule
Weekdays
Reporting Time
Preliminary: 3 days
Additional Information
Clinical Significance: The MHATP/TP.PA assay is recommended by the CDC as a second Treponemal Antibody assay when there are discordant results between a Treponemal assay performed by Multiplex Flow and an RPR assay and there is no known patient history of syphilis or suspicion of current syphilis infection. The MHATP/TP.PA can also be used to confirm the presence or absence of past or current syphilis infection in pregnant women, as pregnant women can have a false positive Treponemal Antibody result by Multiplex Flow Immunoassay, in addition to a false positive low titer RPR result.
Order Remarks: This test is not appropriate for patients < 6 months old. Treponema pallidum Antibody Panel (FTA-ABS) IgG and IgM send out testing should be performed. To request this testing, order LAB2197 (Free Text Lab Order) and specify "Treponema pallidum Antibody Panel (FTA-ABS) IgG and IgM" as test needed.
Regulatory Information: All required results are reported to the appropriate State Health Department.
Order Remarks: This test is not appropriate for patients < 6 months old. Treponema pallidum Antibody Panel (FTA-ABS) IgG and IgM send out testing should be performed. To request this testing, order LAB2197 (Free Text Lab Order) and specify "Treponema pallidum Antibody Panel (FTA-ABS) IgG and IgM" as test needed.
Regulatory Information: All required results are reported to the appropriate State Health Department.
Reflex Criteria
When a Treponema Pallidum IgG TPPA (LAB1308) is reactive and it has been ordered as a reflex from an equivocal Treponema Pallidum Total Antibody (LAB1197), an RPR Qualitative (LAB4108) will be performed and charged (CPT: 86780). RPR Quantitative Titer will be performed and charged when the reflex RPR is reactive (CPT: 86593).
Treponemal pallidum Antibody, IgG by IFA will be performed and charged when Treponema Pallidum IgG TPPA (LAB1308) is inconclusive and Treponema Pallidum Total Antibody (LAB1197) was equivocal.
Treponema Pallidum Total Antibody (LAB1197) will be performed and charged if Treponema Pallidum IgG TPPA (LAB1308) was inconclusive and there is no history of Treponema Pallidum Total Antibody testing at ACL.
Treponemal pallidum Antibody, IgG by IFA will be performed and charged when Treponema Pallidum IgG TPPA (LAB1308) is inconclusive and Treponema Pallidum Total Antibody (LAB1197) was equivocal.
Treponema Pallidum Total Antibody (LAB1197) will be performed and charged if Treponema Pallidum IgG TPPA (LAB1308) was inconclusive and there is no history of Treponema Pallidum Total Antibody testing at ACL.
Stability
Ambient: Unacceptable / Refrigerated: 5 Days / Frozen: 2 Weeks
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